The Effect of a 16-week Home-based Aerobic Exercise Program on Serum High-sensitivity C-Reactive Protein (Hs-CRP) and Insulin Resistance in Polycystic Ovary Syndrome
Published: August 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/41201.13066
Nahid Mohammadi Javid, Naser Behpour, Vahid Tadibi
1. PhD, Department of Sport Physiology, Kermanshah Branch, Islamic Azad University (IAU), Kermanshah, Iran.
2. Associate Professor, Department of Exercise Physiology, School of Sports Sciences, Razi University, Kermanshah, Iran.
3. Assistant Professor, Department of Exercise Physiology, School of Sports Sciences, Razi University, Kermanshah, Iran.
Correspondence
Nahid Mohammadi Javid,
PhD, Department of Sport Physiology, Kermanshah Branch, Islamic Azad University (IAU), Kermanshah, Iran.
E-mail: n.javid76@yahoo.com
Introduction: Polycystic Ovarian Syndrome (PCOS) is one of the most common hormonal disorders that affect 10 to 15% of women of reproductive age. Women with PCOS are at risk for complications such as pregnancy poor outcomes, insulin resistance, Type 2 Diabetes Mellitus (T2DM), metabolic syndrome, cardiovascular diseases and some malignant conditions where increase in serum C-reactive protein (CRP) level is known to be a marker.
Aim: To investigate the effect of a 16-week home-based aerobic exercise program on high-sensitivity CRP (hs-CRP) and insulin resistance index in females with PCOS.
Materials and Methods: In this quasi-experimental study, 24 female patients with PCOS were included and were divided into experimental (a home-based aerobic exercise program for 16 weeks) group (12 subjects) and control group (no intervention, 12 subjects). Serum hs-CRP and insulin resistance index (HOMA-IR) were measured and compared between the two groups. The paired t-test was used to compare the variables at baseline and after 16-weeks.
Results: Mean (±SD) hs-CRP level in experimental group at baseline was 6.31 (±2.64) mg/L which decreased to 3.91 (±1.59) mg/L (p=0.004). Mean (±SD) HOMA-IR in the experimental group at baseline was 3.24 (±1.3) which decreased to 1.87 (±0.47) after 16-weeks. However, no significant change in hs-CRP or HOMA-IR was seen in control group.
Conclusion: The home-based aerobic exercise program had a beneficial effect on improving insulin sensitivity (decrease in HOMA-IR) and reduction in hs-CRP in women with PCOS. This exercise could be recommended as a safe treatment for these patients.
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